Consumption of animal bile including snakes for treatment has been done since centuries and still survive today. In Indonesia, python snake bile is quite popular to cure various diseases.  However, there is not much scientific evidence that can be used as a basis for  the use in the current modern era. This research is a literature study to determine the efficacy and safety of pyton bile consumption. Literature search was conducted in June 2020 through the Google search engine, Google Scholar and PubMed. Keywords: pyton, bile, python, snake and additional words related to the efficacy, safety, taxonomy, content of active substances. The results are pyton  bile has the main content of bile acids Tauropythocholate (TPC), Taurocholate (TC), Taurodeoxycholate (TDC). Deoxycholic acid shows anti-inflammatory activity in vitro, while cholic and deoxycholic bile salts could kill Sthapylococcus aureus bacteria in vitro. Other compounds are protein and antioxidants. Consumption of python bile can provide benefits like bile function itself, namely elimination of toxins, increase the absorption of fat-soluble vitamins and cholesterol. However, Pyton bile can be a source of transmission of several bacteria and parasites. Consumption with high doses (> 2 biles) and routine for a long time can cause damage to liver and kidney. Python bile has the potential for efficacy in accordance with its empirical claims, but it must still be strengthened with experimental  evidence. From the safety side, the consumption of healthy snake bile, in accordance with the dosage and not often is  quite safe.